A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration
BR Miller, C Press, RW Daniels, Y Sasaki… - Nature …, 2009 - nature.com
Nature neuroscience, 2009•nature.com
Axon degeneration underlies many common neurological disorders, but the signaling
pathways that orchestrate axon degeneration are unknown. We found that dual leucine
kinase (DLK) promoted degeneration of severed axons in Drosophila and mice, and that its
target, c-Jun N-terminal kinase, promoted degeneration locally in axons as they committed
to degenerate. This pathway also promoted degeneration after chemotherapy exposure and
may be a component of a general axon self-destruction program.
pathways that orchestrate axon degeneration are unknown. We found that dual leucine
kinase (DLK) promoted degeneration of severed axons in Drosophila and mice, and that its
target, c-Jun N-terminal kinase, promoted degeneration locally in axons as they committed
to degenerate. This pathway also promoted degeneration after chemotherapy exposure and
may be a component of a general axon self-destruction program.
Abstract
Axon degeneration underlies many common neurological disorders, but the signaling pathways that orchestrate axon degeneration are unknown. We found that dual leucine kinase (DLK) promoted degeneration of severed axons in Drosophila and mice, and that its target, c-Jun N-terminal kinase, promoted degeneration locally in axons as they committed to degenerate. This pathway also promoted degeneration after chemotherapy exposure and may be a component of a general axon self-destruction program.
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