Persistent chemoneuropathy in patients receiving the plant alkaloids paclitaxel and vincristine
JA Boyette-Davis, JP Cata, LC Driver, DM Novy… - Cancer chemotherapy …, 2013 - Springer
JA Boyette-Davis, JP Cata, LC Driver, DM Novy, BM Bruel, DL Mooring…
Cancer chemotherapy and pharmacology, 2013•SpringerPurpose Chemoneuropathy remains a painful, burdensome complication of cancer
treatment for patients receiving a range of chemotherapeutics, yet the cause and persistence
of this condition are not fully documented. This study was designed to quantify the longevity
of and contributions to neuropathy following treatment with the plant alkaloids paclitaxel and
vincristine. Methods Quantitative sensory testing was conducted approximately 18 months
apart on 14 patients, seven of which had been treated with paclitaxel and seven with …
treatment for patients receiving a range of chemotherapeutics, yet the cause and persistence
of this condition are not fully documented. This study was designed to quantify the longevity
of and contributions to neuropathy following treatment with the plant alkaloids paclitaxel and
vincristine. Methods Quantitative sensory testing was conducted approximately 18 months
apart on 14 patients, seven of which had been treated with paclitaxel and seven with …
Purpose
Chemoneuropathy remains a painful, burdensome complication of cancer treatment for patients receiving a range of chemotherapeutics, yet the cause and persistence of this condition are not fully documented. This study was designed to quantify the longevity of and contributions to neuropathy following treatment with the plant alkaloids paclitaxel and vincristine.
Methods
Quantitative sensory testing was conducted approximately 18 months apart on 14 patients, seven of which had been treated with paclitaxel and seven with vincristine and compared to data from 18 healthy control subjects. In addition, skin biopsies were obtained to investigate changes in the density of Meissner’s corpuscles and epidermal nerve fibers (ENFs), the loss of which is thought to contribute to multiple forms of neuropathy.
Results
Impairments in motor skills, as measured by a grooved peg-board, were found. Deficits in touch detection were observed using von Frey monofilaments, as were changes in sharpness detection using a weighted needle device. Using a Peltier device, warmth and heat detection were impaired. These deficits were consistent across time. Remarkably, the average length of time patients reported painful neuropathy was over four and a half years. Skin biopsies were found to be deficient in Meissner’s corpuscles and ENFs.
Conclusions
The combination of widespread deficits in sensory testing and decreases in skin innervation for cancer patients receiving paclitaxel or vincristine document a persistent polyneuropathy which severely impacts these patients. Decreases in Meissner’s corpuscles and ENFs indicate a possible mechanism for the neuropathy.
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