High fat maintenance diet attenuates hindbrain neuronal response to CCK

M Covasa, J Grahn, RC Ritter - Regulatory peptides, 2000 - Elsevier
Rats maintained on a high fat diet reduce their food intake less in response to exogenous
cholecystokinin (CCK) than rats maintained on a low fat diet. In addition, inhibition of gastric
emptying by CCK is markedly attenuated in rats maintained on a high fat diet. Both inhibition
of food intake and gastric emptying by CCK are mediated by sensory fibers in the vagus
nerve. These fibers terminate on dorsal hindbrain neurons of the nucleus of the solitary tract
and area postrema. To determine whether diet-induced changes in the control of feeding …