Rats maintained on high-fat diets often exhibit increased food intake and weight gain. We
hypothesized that high-fat diets might result in reduced sensitivity to hormonal signals
responsible for terminating food intake—satiety signals. The intestinal hormone
cholecystokinin (CCK) and the gastrointestinal neuropeptide, bombesin (BBS) both have
been proposed as satiety signals. To determine whether maintenance on high-fat diets
alters sensitivity to satiating effects of CCK and bombesin (BBS), rats were maintained on a …