[HTML][HTML] Adaptation to a high-fat diet leads to hyperphagia and diminished sensitivity to cholecystokinin in rats

DM Savastano, M Covasa - The Journal of nutrition, 2005 - Elsevier
Rats fed high-fat (HF) diets exhibit reduced sensitivity to some peptide satiety signals. We
hypothesized that reduced sensitivity to satiety signals might contribute to overconsumption
of a high-energy food after adaptation to HF diets. To test this, we measured daily, 3-h intake
of a high-energy, high-fat (HHF, 22.3 kJ/g) test food in rats fed either low-fat (LF) or HF,
isoenergetic (16.2 kJ/g) diets. During testing, half of each group received the HHF test food
(LF/HHF; HF/HHF), whereas the other half received their respective maintenance diet …