[HTML][HTML] E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress
M Otero, DA Plumb, K Tsuchimochi… - Journal of Biological …, 2012 - ASBMB
Matrix metalloproteinase (MMP)-13 has a pivotal, rate-limiting function in cartilage
remodeling and degradation due to its specificity for cleaving type II collagen. The proximal
MMP13 promoter contains evolutionarily conserved E26 transformation-specific sequence
binding sites that are closely flanked by AP-1 and Runx2 binding motifs, and interplay
among these and other factors has been implicated in regulation by stress and inflammatory
signals. Here we report that ELF3 directly controls MMP13 promoter activity by targeting an …
remodeling and degradation due to its specificity for cleaving type II collagen. The proximal
MMP13 promoter contains evolutionarily conserved E26 transformation-specific sequence
binding sites that are closely flanked by AP-1 and Runx2 binding motifs, and interplay
among these and other factors has been implicated in regulation by stress and inflammatory
signals. Here we report that ELF3 directly controls MMP13 promoter activity by targeting an …