[HTML][HTML] von Willebrand factor and inflammation

C Kawecki, PJ Lenting, CV Denis - Journal of Thrombosis and Haemostasis, 2017 - Elsevier
Von Willebrand factor (VWF) is a plasma glycoprotein best known for its crucial hemostatic
role in serving as a molecular bridge linking platelets to subendothelial components
following vascular injury. In addition, VWF functions as chaperone for coagulation factor VIII.
In pathological settings, VWF is recognized as a risk factor for both arterial and venous
thrombosis, as well as a molecular player that directly promotes the thrombotic process.
Recent years have seen the emergence of the concept of immuno‐thrombosis by which …