Disorders of water balance, an excess or deficit of total body water relative to body
electrolyte content, are common and ascertained by plasma hypo-or hypernatremia,
respectively. We performed a two-stage genome-wide association study meta-analysis on
plasma sodium concentration in 45,889 individuals of European descent (stage 1 discovery)
and 17,637 additional individuals of European descent (stage 2 replication), and a
transethnic meta-analysis of replicated single-nucleotide polymorphisms in 79,506 …