Ten years later Hoppe-Seyler, Jr. 39 found that transient glycosuria could occasionally be observed in malnourished, half-starved persons during the first few days of hospitalization. More recently the glycosuria of starvation diabetes has been studied by Winther. 82 He found that the glycosuria which appears when a high carbohydrate diet is forcibly fed to rats after they have been starved for some time is proportional to the length of the previous period of starvation.

Claude Bernard's discovery of starvation diabetes was one of the results of his ingenious application to many different phases of car-bohydrate metabolism of a chemical method for the determination of glucose, namely, Trommer's copper sulfate method published a few years earlier. 77 By the same token, further developments in the inves-tigation of starvation diabetes had to await the introduction and applica-tion of new methods for the study of carbohydrate metabolism. The following review will discuss the metabolic abnormalities that have been shown to exist in starvation diabetes, dividing the topic ac-cording to the different methods of investigation that have been applied.