Tissue and blood T-lymphocyte subpopulations in erythema nodosum leprosum
RL Modlin, AC Bakke, SA Vaccaro… - Archives of …, 1985 - jamanetwork.com
• To study T lymphocytes in erythema nodosum leprosum (ENL), monoclonal antibodies
were used to identify T-lymphocyte subpopulations in the blood and skin lesions of patients
with ENL and patients with nonreactional lepromatous leprosy. The blood of nonreactional
lepromatous patients had a lymphopenia and a proportionate reduction in pan T cells,
helper-inducer, and suppressor-cytotoxic subsets, but a normal helper-suppressor ratio, as
compared with controls. Patients with ENL did not differ significantly from the controls. In skin …
were used to identify T-lymphocyte subpopulations in the blood and skin lesions of patients
with ENL and patients with nonreactional lepromatous leprosy. The blood of nonreactional
lepromatous patients had a lymphopenia and a proportionate reduction in pan T cells,
helper-inducer, and suppressor-cytotoxic subsets, but a normal helper-suppressor ratio, as
compared with controls. Patients with ENL did not differ significantly from the controls. In skin …