[HTML][HTML] The regulation of uncoupling protein-2 gene expression by ω-6 polyunsaturated fatty acids in human skeletal muscle cells involves multiple pathways …
E Chevillotte, J Rieusset, M Roques, M Desage… - Journal of Biological …, 2001 - ASBMB
Fatty acids have been postulated to regulate uncoupling protein (UCP) gene expression in
skeletal musclein vivo. We have identified, at least in part, the mechanism by which
polyunsaturated fatty acids increase UCP-2 expression in primary culture of human muscle
cells. ω-6 fatty acids and arachidonic acid induced a 3-fold rise in UCP-2 mRNA levels
possibly through transcriptional activation. This effect was prevented by indomethacin and
mimicked by prostaglandin (PG) E 2 and carbaprostacyclin PGI 2, consistent with a …
skeletal musclein vivo. We have identified, at least in part, the mechanism by which
polyunsaturated fatty acids increase UCP-2 expression in primary culture of human muscle
cells. ω-6 fatty acids and arachidonic acid induced a 3-fold rise in UCP-2 mRNA levels
possibly through transcriptional activation. This effect was prevented by indomethacin and
mimicked by prostaglandin (PG) E 2 and carbaprostacyclin PGI 2, consistent with a …