Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis
MC Caino, VA von Burstin, C Lopez-Haber… - Journal of Biological …, 2011 - ASBMB
Protein kinase C (PKC) isozymes are key signal transducers involved in normal physiology
and disease and have been widely implicated in cancer progression. Despite our extensive
knowledge of the signaling pathways regulated by PKC isozymes and their effectors, there is
essentially no information on how individual members of the PKC family regulate gene
transcription. Here, we report the first PKC isozyme-specific analysis of global gene
expression by microarray using RNAi depletion of diacylglycerol/phorbol ester-regulated …
and disease and have been widely implicated in cancer progression. Despite our extensive
knowledge of the signaling pathways regulated by PKC isozymes and their effectors, there is
essentially no information on how individual members of the PKC family regulate gene
transcription. Here, we report the first PKC isozyme-specific analysis of global gene
expression by microarray using RNAi depletion of diacylglycerol/phorbol ester-regulated …
