[HTML][HTML] Characterization of the extra-large G protein α-subunit XLαs: II. Signal transduction properties

M Klemke, HA Pasolli, RH Kehlenbach… - Journal of Biological …, 2000 - ASBMB
In the preceding paper (Pasolli, HA, Klemke, M., Kehlenbach, RH, Wang, Y., and Huttner,
WB (2000) J. Biol. Chem. 275, 33622–33632), we report on the tissue distribution and
subcellular localization of XLαs (extra large αs), a neuroendocrine-specific, plasma
membrane-associated protein consisting of a novel 37-kDa XL domain followed by a 41-kDa
αs domain encoded by exons 2-13 of the Gαs gene. Here, we have studied the signal
transduction properties of XLαs. Like Gαs, XLαs undergoes a conformational change upon …