Fibroblastic growth factor receptor 1 (FGFR1) signaling pathways are implicated in the
regulation of FGF-23 gene transcription, but the molecular pathways remain poorly defined.
We used low molecular weight (LMW, 18 kDa) FGF-2 and high molecular weight (HMW)
FGF-2 isoforms, which, respectively, activate cell surface FGF receptors and intranuclear
FGFR1, to determine the roles of membrane FGFRs and integrative nuclear FGFR1
signaling (INFS) in the regulation of FGF-23 gene transcription in osteoblasts. We found that …