Dual action of androgen on calcium signaling and luteinizing hormone secretion in pituitary gonadotrophs
O Ortmann, M Tomic, JM Weiss, K Diedrich… - Cell Calcium, 1998 - Elsevier
An increase in serum androgen levels associated with a suppression of cyclic gonadotropin
secretion is frequently observed in females with impaired ovarian function. Here, we
addressed the hypotheses that androgens (testosterone and dihydrotestosterone) alter
gonadotropin secretion by modulating agonist-induced Ca2+ signaling and/or Ca2+-
controlled exocytosis. In mixed populations of pituitary cells from female rats, addition of
testosterone reduced basal and agonist (GnRH)-induced gonadotropin secretion in a …
secretion is frequently observed in females with impaired ovarian function. Here, we
addressed the hypotheses that androgens (testosterone and dihydrotestosterone) alter
gonadotropin secretion by modulating agonist-induced Ca2+ signaling and/or Ca2+-
controlled exocytosis. In mixed populations of pituitary cells from female rats, addition of
testosterone reduced basal and agonist (GnRH)-induced gonadotropin secretion in a …