Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF
N Esumi, M Budarf, L Ciccarelli, B Sellinger… - Mammalian …, 1998 - Springer
N Esumi, M Budarf, L Ciccarelli, B Sellinger, CA Kozak, G Wistow
Mammalian Genome, 1998•SpringerMacrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) are
small proteins, which are related both by sequence and by in vitro enzyme activity. Here we
show that the gene for DDT in human and mouse is identical in exon structure to MIF. Both
genes have two introns that are located at equivalent positions, relative to a twofold repeat in
protein structure. Although in similar positions, the introns are in different phases relative to
the open reading frame. Other members of this superfamily exist in nematodes and a plant …
small proteins, which are related both by sequence and by in vitro enzyme activity. Here we
show that the gene for DDT in human and mouse is identical in exon structure to MIF. Both
genes have two introns that are located at equivalent positions, relative to a twofold repeat in
protein structure. Although in similar positions, the introns are in different phases relative to
the open reading frame. Other members of this superfamily exist in nematodes and a plant …
Abstract
Macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) are small proteins, which are related both by sequence and by in vitro enzyme activity. Here we show that the gene for DDT in human and mouse is identical in exon structure to MIF. Both genes have two introns that are located at equivalent positions, relative to a twofold repeat in protein structure. Although in similar positions, the introns are in different phases relative to the open reading frame. Other members of this superfamily exist in nematodes and a plant, and a related gene in C. elegans shares an intron position with MIF and DDT. In addition to similarities in structure, the genes for DDT and MIF are closely linked on human Chromosome (Chr) 22 and mouse Chr 10.
Springer