Pioneer transcription factors have the unique and important role of unmasking chromatin
domains during development to allow the implementation of new cellular programs.
Compared with those of other transcription factors, this activity implies that pioneer factors
can recognize their target DNA sequences in so-called compacted or" closed"
heterochromatin and can trigger remodeling of the adjoining chromatin landscape to provide
accessibility to nonpioneer transcription factors. Recent studies identified several steps of …