[HTML][HTML] Mechanistic target of rapamycin controls homeostasis of adipogenesis

MS Yoon, C Zhang, Y Sun, CJ Schoenherr… - Journal of lipid …, 2013 - ASBMB
Signaling mediated by the mechanistic target of rapamycin (mTOR) is believed to play a
critical and positive role in adipogenesis, based on pharmacological evidence and genetic
manipulation of mTOR regulators and targets. However, there is no direct genetic evidence
for an autonomous role of mTOR itself in preadipocyte differentiation. To seek such
evidence, we employed a conditional knockdown approach to deplete mTOR in
preadipocytes. Surprisingly, while knockdown of S6K1, a target of mTOR, impairs 3T3-L1 …