Use of quantitative membrane proteomics identifies a novel role of mitochondria in healing injured muscles

N Sharma, S Medikayala, A Defour… - Journal of biological …, 2012 - jbc.org
Skeletal muscles are proficient at healing from a variety of injuries. Healing occurs in two
phases, early and late phase. Early phase involves healing the injured sarcolemma and
restricting the spread of damage to the injured myofiber. Late phase of healing occurs a few
days postinjury and involves interaction of injured myofibers with regenerative and
inflammatory cells. Of the two phases, cellular and molecular processes involved in the early
phase of healing are poorly understood. We have implemented an improved sarcolemmal …