[HTML][HTML] The critical impact of HIF-1α on gastric cancer biology

Y Kitajima, K Miyazaki - Cancers, 2013 - mdpi.com
Y Kitajima, K Miyazaki
Cancers, 2013mdpi.com
Hypoxia inducible factor-1 (HIF-1) monitors the cellular response to the oxygen levels in
solid tumors. Under hypoxia conditions, HIF-1α protein is stabilized and forms a heterodimer
with the HIF-1β subunit. The HIF-1 complex activates the transcription of numerous target
genes in order to adapt the hypoxic environment in human cancer cells. In gastric cancer
patients, HIF-1α activation following extended hypoxia strongly correlates with an
aggressive tumor phenotype and a poor prognosis. HIF-1α activation has been also …
Hypoxia inducible factor-1 (HIF-1) monitors the cellular response to the oxygen levels in solid tumors. Under hypoxia conditions, HIF-1α protein is stabilized and forms a heterodimer with the HIF-1β subunit. The HIF-1 complex activates the transcription of numerous target genes in order to adapt the hypoxic environment in human cancer cells. In gastric cancer patients, HIF-1α activation following extended hypoxia strongly correlates with an aggressive tumor phenotype and a poor prognosis. HIF-1α activation has been also reported to occur via hypoxia-independent mechanisms such as PI3K/AKT/mTOR signaling and ROS production. This article argues for the critical roles of HIF-1α in glucose metabolism, carcinogenesis, angiogenesis, invasion, metastasis, cell survival and chemoresistance, focusing on gastric cancer.
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