Differential binding and transcriptional behaviour of two highly related orphan receptors, RORα4 and RORβ1

K Gawlas, HG Stunnenberg - Biochimica et Biophysica Acta (BBA)-Gene …, 2000 - Elsevier
Nuclear receptors are ligand-inducible transcription factors that can be classified into two
major groups according to their DNA-binding properties. Members of the first group bind to
DNA as dimers, either homo-or heterodimers; members of the second group are also able to
bind as monomers. While the first group has been extensively studied biochemically, very
little is known about nuclear receptors that bind and act as monomers. In this study, we
compared the binding and transcriptional behaviour of RORα (NR1F1) and RORβ (NR1F2) …