PP2A regulates the pro-apoptotic activity of FOXO1
L Yan, VA Lavin, LR Moser, Q Cui, C Kanies… - Journal of Biological …, 2008 - jbc.org
FOXO1, a member of the evolutionarily conserved forkhead family of transcription factors,
regulates expression of a number of genes that play critical roles in cell cycle and apoptosis.
A pivotal regulatory mechanism of FOXO is reversible phosphorylation, catalyzed by kinases
and phosphatases. Phosphorylation of FOXO1 is associated with 14-3-3 binding and
cytosolic localization, whereas dephosphorylated FOXO1 translocates to the nucleus and is
transcriptionally active. Experiments were performed to identify the serine/threonine …
regulates expression of a number of genes that play critical roles in cell cycle and apoptosis.
A pivotal regulatory mechanism of FOXO is reversible phosphorylation, catalyzed by kinases
and phosphatases. Phosphorylation of FOXO1 is associated with 14-3-3 binding and
cytosolic localization, whereas dephosphorylated FOXO1 translocates to the nucleus and is
transcriptionally active. Experiments were performed to identify the serine/threonine …