[HTML][HTML] Multicenter Australian trial of islet transplantation: improving accessibility and outcomes
PJ O'Connell, DJ Holmes-Walker, D Goodman… - American Journal of …, 2013 - Elsevier
Whilst initial rates of insulin independence following islet transplantation are encouraging,
long-term function using the Edmonton Protocol remains a concern. The aim of this single-
arm, multicenter study was to evaluate an immunosuppressive protocol of initial
antithymocyte globulin (ATG), tacrolimus and mycophenolate mofetil (MMF) followed by
switching to sirolimus and MMF. Islets were cultured for 24 h prior to transplantation. The
primary end-point was an HbA1c of< 7% and cessation of severe hypoglycemia. Seventeen …
long-term function using the Edmonton Protocol remains a concern. The aim of this single-
arm, multicenter study was to evaluate an immunosuppressive protocol of initial
antithymocyte globulin (ATG), tacrolimus and mycophenolate mofetil (MMF) followed by
switching to sirolimus and MMF. Islets were cultured for 24 h prior to transplantation. The
primary end-point was an HbA1c of< 7% and cessation of severe hypoglycemia. Seventeen …