Different 2-aminothiazole therapeutics produce distinct patterns of scrapie prion neuropathology in mouse brains
Because no drug exists that halts or even slows any neurodegenerative disease, developing
effective therapeutics for any prion disorder is urgent. We recently reported two compounds
(IND24 and IND81) with the 2-aminothiazole (2-AMT) chemical scaffold that almost doubled
the incubation times in scrapie prion-infected, wild-type (wt) FVB mice when given in a liquid
diet. Remarkably, oral prophylactic treatment with IND24 beginning 14 days prior to
intracerebral prion inoculation extended survival from∼ 120 days to over 450 days. In …
effective therapeutics for any prion disorder is urgent. We recently reported two compounds
(IND24 and IND81) with the 2-aminothiazole (2-AMT) chemical scaffold that almost doubled
the incubation times in scrapie prion-infected, wild-type (wt) FVB mice when given in a liquid
diet. Remarkably, oral prophylactic treatment with IND24 beginning 14 days prior to
intracerebral prion inoculation extended survival from∼ 120 days to over 450 days. In …