[HTML][HTML] The role of TGF-β in growth, differentiation, and maturation of B lymphocytes
DA Lebman, JS Edmiston - Microbes and infection, 1999 - Elsevier
Transforming growth factor-β (TGF-β) affects B cells at all stages in development. It appears
to be involved in lymphopoiesis and is required for the development of plasma cells
secreting all secondary isotypes. Its ability to inhibit proliferation and stimulate apoptosis
suggest that it may be involved both in germinal center development and regulation of B-cell
proliferation at sites of high antigen load such as the gastrointestinal tract. Although TGF-β
appears to be required for the generation of B cells secreting secondary isotypes, it inhibits …
to be involved in lymphopoiesis and is required for the development of plasma cells
secreting all secondary isotypes. Its ability to inhibit proliferation and stimulate apoptosis
suggest that it may be involved both in germinal center development and regulation of B-cell
proliferation at sites of high antigen load such as the gastrointestinal tract. Although TGF-β
appears to be required for the generation of B cells secreting secondary isotypes, it inhibits …