Inhibition and covalent modification of tyrosine hydroxylase by 3, 4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite
LM Mexas, VR Florang, JA Doorn - Neurotoxicology, 2011 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder marked by the selective loss of
dopaminergic neurons, leading to a decrease of the neurotransmitter dopamine (DA). DA is
metabolized by monoamine oxidase to 3, 4-dihydroxyphenyacetaldehyde (DOPAL). While
the mechanism of pathogenesis of PD is unknown, DOPAL has demonstrated the ability to
covalently modify proteins and cause cell death at concentrations elevated from physiologic
levels. Currently, the identities of protein targets of the aldehyde are unknown, but previous …
dopaminergic neurons, leading to a decrease of the neurotransmitter dopamine (DA). DA is
metabolized by monoamine oxidase to 3, 4-dihydroxyphenyacetaldehyde (DOPAL). While
the mechanism of pathogenesis of PD is unknown, DOPAL has demonstrated the ability to
covalently modify proteins and cause cell death at concentrations elevated from physiologic
levels. Currently, the identities of protein targets of the aldehyde are unknown, but previous …