Level of Granzyme B-positive T-regulatory cells is a strong predictor biomarker of acute Graft-versus-host disease after day+ 30 after allo-HSCT

MY Drokov, JO Davydova, LA Kuzmina, IV Galtseva… - Leukemia Research, 2017 - Elsevier
Acute Graft-versus-host-disease (aGVHD), the major complication and one of the main
causes of poor outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Nowadays there are no widely accepted cell, plasma or another biomarker that can be used
for aGVHD prediction. We hypothesized that a level of Granzyme B-positive T regulatory
(GZMB-positive Treg) cells on day+ 30 after allo-HSCT could be the measure of immune
response suppression and could predict aGVHD development after day+ 30. We applied a …