[HTML][HTML] Wild type α-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
T Vogiatzi, M Xilouri, K Vekrellis, L Stefanis - Journal of Biological …, 2008 - ASBMB
α-Synuclein (ASYN) is crucial in Parkinson disease (PD) pathogenesis. Increased levels of
wild type (WT) ASYN expression are sufficient to cause PD in humans. The manner of post-
transcriptional regulation of ASYN levels is controversial. Previously, we had shown that WT
ASYN can be degraded by chaperone-mediated autophagy (CMA) in isolated liver
lysosomes. Whether this occurs in a cellular and, in particular, in a neuronal cell context is
unclear. Using a mutant ASYN form that lacks the CMA recognition motif and RNA …
wild type (WT) ASYN expression are sufficient to cause PD in humans. The manner of post-
transcriptional regulation of ASYN levels is controversial. Previously, we had shown that WT
ASYN can be degraded by chaperone-mediated autophagy (CMA) in isolated liver
lysosomes. Whether this occurs in a cellular and, in particular, in a neuronal cell context is
unclear. Using a mutant ASYN form that lacks the CMA recognition motif and RNA …