[HTML][HTML] 2-hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy
2-Hydroxypropyl-β-cyclodextrin (HPβCD) is a Food and Drug Administration-approved
excipient used to improve the stability and bioavailability of drugs. Despite its wide use as a
drug delivery vehicle and the recent approval of a clinical trial to evaluate its potential for the
treatment of a cholesterol storage disorder, the cellular pathways involved in the adaptive
response that is activated upon exposure to HPβCD are still poorly defined. Here, we show
that cell treatment with HPβCD results in the activation of the transcription factor EB, a …
excipient used to improve the stability and bioavailability of drugs. Despite its wide use as a
drug delivery vehicle and the recent approval of a clinical trial to evaluate its potential for the
treatment of a cholesterol storage disorder, the cellular pathways involved in the adaptive
response that is activated upon exposure to HPβCD are still poorly defined. Here, we show
that cell treatment with HPβCD results in the activation of the transcription factor EB, a …