[PDF][PDF] Clinical significance of striatal DOPA decarboxylase activity in Parkinson's disease
T Ishikawa, V Dhawan, T Chaly… - Journal of Nuclear …, 1996 - Soc Nuclear Med
T Ishikawa, V Dhawan, T Chaly, C Margouleff, W Robeson, JR Dahl, F Mandel, P Spetsieris…
Journal of Nuclear Medicine, 1996•Soc Nuclear MedResults: Afthough DDC activity has been postulated as a precise indicatorof
presynapticnigrostnataldopaminergicfunction, K@ FD and SOR provided better between-
group discrimination than did estimatesof stñatalDDC activity. ià § @ arid k@ 9pop) both
correlated significantlywith quantitativediseaseseverityratings, with a similar degree of
accuracy (r= 0.69 and 0.63 for k@ Â (pop) and IÃ § @@ t), respective'y; p< 0.01).
Conclusion: Although estimated stilatal DDC activity correlates with clinical d@ aI@ Iity, this …
presynapticnigrostnataldopaminergicfunction, K@ FD and SOR provided better between-
group discrimination than did estimatesof stñatalDDC activity. ià § @ arid k@ 9pop) both
correlated significantlywith quantitativediseaseseverityratings, with a similar degree of
accuracy (r= 0.69 and 0.63 for k@ Â (pop) and IÃ § @@ t), respective'y; p< 0.01).
Conclusion: Although estimated stilatal DDC activity correlates with clinical d@ aI@ Iity, this …
Results: Afthough DDC activity has been postulated as a precise indicatorof presynapticnigrostnataldopaminergicfunction, K@ FD and SOR provided better between-group discrimination than did estimatesof stñatalDDC activity. ià § @ arid k@ 9pop) both correlated significantlywith quantitativediseaseseverityratings, with a similar degree of accuracy (r= 0.69 and 0.63 for k@  (pop) and Ià § @@ t), respective'y; p< 0.01). Conclusion: Although estimated stilatal DDC activity correlates with clinical d@ aI@ Iity, this measure is comparably less effective for early diagnosis. We conclude that a elmp@ estimate suth as stiiatal Ià § F@@ to@ D@ f@@ clinical and research app@ ations.
Society of Nuclear Medicine and Molecular Imaging