[HTML][HTML] Translational opportunities for targeting the Th17 axis in acute graft-vs.-host disease
F Malard, B Gaugler, B Lamarthee, M Mohty - Mucosal Immunology, 2016 - Elsevier
Allogeneic stem cell transplantation (allo-SCT) is a curative therapy for different life-
threatening malignant and non-malignant hematologic disorders. Acute graft-vs.-host
disease (aGVHD) and particularly gastrointestinal aGVHD remains a major source of
morbidity and mortality following allo-SCT, which limits the use of this treatment in a broader
spectrum of patients. Better understanding of aGVHD pathophysiology is indispensable to
identify new therapeutic targets for aGVHD prevention and therapy. Growing amount of data …
threatening malignant and non-malignant hematologic disorders. Acute graft-vs.-host
disease (aGVHD) and particularly gastrointestinal aGVHD remains a major source of
morbidity and mortality following allo-SCT, which limits the use of this treatment in a broader
spectrum of patients. Better understanding of aGVHD pathophysiology is indispensable to
identify new therapeutic targets for aGVHD prevention and therapy. Growing amount of data …