Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets
MA Mitsche, HH Hobbs, JC Cohen - Journal of Biological Chemistry, 2018 - jbc.org
Fatty liver disease (FLD) is a burgeoning health problem. A missense variant (I148M) in
patatin-like phospholipase domain–containing protein 3 (PNPLA3) confers susceptibility to
FLD, although the mechanism is not known. To glean first insights into the physiological
function of PNPLA3, we performed detailed lipidomic profiling of liver lysates and lipid
droplets (LDs) from WT and Pnpla3−/−(KO) mice and from knock-in (ki) mice expressing
either the 148M variant (IM-ki mice) or a variant (S47A) that renders the protein catalytically …
patatin-like phospholipase domain–containing protein 3 (PNPLA3) confers susceptibility to
FLD, although the mechanism is not known. To glean first insights into the physiological
function of PNPLA3, we performed detailed lipidomic profiling of liver lysates and lipid
droplets (LDs) from WT and Pnpla3−/−(KO) mice and from knock-in (ki) mice expressing
either the 148M variant (IM-ki mice) or a variant (S47A) that renders the protein catalytically …