[HTML][HTML] Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans
K Sevastianova, A Santos, A Kotronen… - The American journal of …, 2012 - Elsevier
Background: Cross-sectional studies have identified a high intake of simple sugars as an
important dietary factor predicting nonalcoholic fatty liver disease (NAFLD). Objective: We
examined whether overfeeding overweight subjects with simple sugars increases liver fat
and de novo lipogenesis (DNL) and whether this is reversible by weight loss. Design:
Sixteen subjects [BMI (kg/m 2): 30.6±1.2] were placed on a hypercaloric diet (> 1000 kcal
simple carbohydrates/d) for 3 wk and, thereafter, on a hypocaloric diet for 6 mo. The subjects …
important dietary factor predicting nonalcoholic fatty liver disease (NAFLD). Objective: We
examined whether overfeeding overweight subjects with simple sugars increases liver fat
and de novo lipogenesis (DNL) and whether this is reversible by weight loss. Design:
Sixteen subjects [BMI (kg/m 2): 30.6±1.2] were placed on a hypercaloric diet (> 1000 kcal
simple carbohydrates/d) for 3 wk and, thereafter, on a hypocaloric diet for 6 mo. The subjects …