Insulin inhibits glucagon-induced glycogenolysis in perivenous hepatocytes specifically
Y Ikezawa, K Yamatani, H Ohnuma, M Igarashi… - Journal of Laboratory …, 2001 - Elsevier
Hepatocytes form the hepatic acinus as the unit of microcirculation. Following the
bloodstream, at least 2 different zones can be discerned: the periportal and perivenous
zones. Two types of hepatocytes, periportal hepatocytes (PPHs) and perivenous
hepatocytes (PVHs), have been thought to be functionally heterogeneous, with PPHs being
predominantly gluconeogenic and PVHs being glycolytic. We therefore investigated the
region-specific functional effects of insulin on glycogen synthesis, glycolysis, glycogenolysis …
bloodstream, at least 2 different zones can be discerned: the periportal and perivenous
zones. Two types of hepatocytes, periportal hepatocytes (PPHs) and perivenous
hepatocytes (PVHs), have been thought to be functionally heterogeneous, with PPHs being
predominantly gluconeogenic and PVHs being glycolytic. We therefore investigated the
region-specific functional effects of insulin on glycogen synthesis, glycolysis, glycogenolysis …