[HTML][HTML] NADPH oxidase 4 (Nox4) suppresses mitochondrial biogenesis and bioenergetics in lung fibroblasts via a nuclear factor erythroid-derived 2-like 2 (Nrf2) …
K Bernard, NJ Logsdon, V Miguel… - Journal of Biological …, 2017 - ASBMB
Mitochondrial bioenergetics are critical for cellular homeostasis and stress responses. The
reactive oxygen species-generating enzyme, NADPH oxidase 4 (Nox4), regulates a number
of physiological and pathological processes, including cellular differentiation, host defense,
and tissue fibrosis. In this study we explored the role of constitutive Nox4 activity in
regulating mitochondrial function. An increase in mitochondrial oxygen consumption and
reserve capacity was observed in murine and human lung fibroblasts with genetic deficiency …
reactive oxygen species-generating enzyme, NADPH oxidase 4 (Nox4), regulates a number
of physiological and pathological processes, including cellular differentiation, host defense,
and tissue fibrosis. In this study we explored the role of constitutive Nox4 activity in
regulating mitochondrial function. An increase in mitochondrial oxygen consumption and
reserve capacity was observed in murine and human lung fibroblasts with genetic deficiency …