[HTML][HTML] Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury
P Roversi, B Ryffel, D Togbe, I Maillet… - Journal of Biological …, 2013 - ASBMB
Molecules that simultaneously inhibit independent or co-dependent proinflammatory
pathways may have advantages over conventional monotherapeutics. OmCI is a
bifunctional protein derived from blood-feeding ticks that specifically prevents complement
(C)-mediated C5 activation and also sequesters leukotriene B4 (LTB 4) within an internal
binding pocket. Here, we examined the effect of LTB 4 binding on OmCI structure and
function and investigated the relative importance of C-mediated C5 activation and LTB 4 in a …
pathways may have advantages over conventional monotherapeutics. OmCI is a
bifunctional protein derived from blood-feeding ticks that specifically prevents complement
(C)-mediated C5 activation and also sequesters leukotriene B4 (LTB 4) within an internal
binding pocket. Here, we examined the effect of LTB 4 binding on OmCI structure and
function and investigated the relative importance of C-mediated C5 activation and LTB 4 in a …