[HTML][HTML] In vivo characterization and therapeutic efficacy of a C5-specific inhibitor from the soft tick Ornithodoros moubata
NJ Hepburn, AS Williams, MA Nunn… - Journal of biological …, 2007 - ASBMB
The involvement of complement (C) in inflammatory diseases has driven the search for
agents capable of inhibiting dysregulated complement activation. Many of these reagents
inhibit the C3 convertases during the early stages of the cascade. However, a drawback of
total systemic C inhibition, particularly in longterm treatment of chronic disease, is
potentiation of infection and immune complex disease due to an inability to opsonize
complexes and foreign cells and to lyse pathogens. Recent identification of a C5-binding …
agents capable of inhibiting dysregulated complement activation. Many of these reagents
inhibit the C3 convertases during the early stages of the cascade. However, a drawback of
total systemic C inhibition, particularly in longterm treatment of chronic disease, is
potentiation of infection and immune complex disease due to an inability to opsonize
complexes and foreign cells and to lyse pathogens. Recent identification of a C5-binding …