[PDF][PDF] Mitochondrial function: OMA1 and OPA1, the grandmasters of mitochondrial health
H McBride, V Soubannier - Current Biology, 2010 - cell.com
Current Biology, 2010•cell.com
Mitochondrial Function: OMA1 and OPA1, the Grandmasters of Mitochondrial Health Page 1
McVean, GA, Gabriel, SB, Reich, D., Donnelly, P., et al. (2005). Comparison of fine-scale
recombination rates in humans and chimpanzees. Science 308, 107–111. 14. Ptak, SE, Hinds,
DA, Koehler, K., Nickel, B., Patil, N., Ballinger, DG, Przeworski, M., Frazer, KA, and Paabo, S.
(2005). Fine-scale recombination patterns differ between chimpanzees and humans. Nat. Genet.
37, 429–434. 15. Mihola, O., Trachtulec, Z., Vlcek, C., Schimenti, JC, and Forejt, J. (2009). A …
McVean, GA, Gabriel, SB, Reich, D., Donnelly, P., et al. (2005). Comparison of fine-scale
recombination rates in humans and chimpanzees. Science 308, 107–111. 14. Ptak, SE, Hinds,
DA, Koehler, K., Nickel, B., Patil, N., Ballinger, DG, Przeworski, M., Frazer, KA, and Paabo, S.
(2005). Fine-scale recombination patterns differ between chimpanzees and humans. Nat. Genet.
37, 429–434. 15. Mihola, O., Trachtulec, Z., Vlcek, C., Schimenti, JC, and Forejt, J. (2009). A …
Summary
Two new studies have identified a key protease responsible for sensing mitochondrial dysfunction, leading to the inactivation of the fusion GTPase OPA1. These studies have broad implications in mitochondrial quality control.
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