[HTML][HTML] Novel protective mechanism for interleukin-33 at the mucosal barrier during influenza-associated bacterial superinfection

KM Robinson, K Ramanan, ME Clay, KJ McHugh… - Mucosal …, 2018 - Elsevier
Influenza A is a highly contagious respiratory virus that causes seasonal epidemics and
occasional worldwide pandemics. The primary cause of influenza-related mortality is
bacterial superinfection. There are numerous mechanisms by which preceding influenza
infection attenuates host defense, allowing for increased susceptibility to bacterial
pneumonia. Herein, we demonstrate that influenza inhibits Staphylococcus aureus-induced
production of interleukin-33 (IL-33). Restoration of IL-33 during influenza A and methicillin …