[HTML][HTML] Mechanisms of neutralization of a human anti-α-toxin antibody
V Oganesyan, L Peng, MM Damschroder… - Journal of Biological …, 2014 - ASBMB
MEDI4893 is a neutralizing human monoclonal antibody that targets α-toxin (AT) and is
currently undergoing evaluation in the field of Staphylococcus aureus-mediated diseases.
We have solved the crystal structure of MEDI4893 Fab bound to monomeric AT at a
resolution of 2.56 Å and further characterized its epitope using various engineered AT
variants. We have found that MEDI4893 recognizes a novel epitope in the so-called" rim"
domain of AT and exerts its neutralizing effect through a dual mechanism. In particular …
currently undergoing evaluation in the field of Staphylococcus aureus-mediated diseases.
We have solved the crystal structure of MEDI4893 Fab bound to monomeric AT at a
resolution of 2.56 Å and further characterized its epitope using various engineered AT
variants. We have found that MEDI4893 recognizes a novel epitope in the so-called" rim"
domain of AT and exerts its neutralizing effect through a dual mechanism. In particular …