Insights into the pore of the hair cell transducer channel from experiments with permeant blockers
SM van Netten, CJ Kros - Current Topics in Membranes, 2007 - Elsevier
Publisher Summary This chapter presents recent experiments designed to infer the
properties of the ion-conducting pore of the mechanoelectrical transducer channel of
sensory hair cells using permeant blockers. By combining results from experiments with
three classes of large cationic permeant blockers, the fluorescent dye FM1-43, the
aminoglycoside antibiotics, and the potassium-sparing diuretic amiloride, information has
been obtained on the free energy profile along the transducer channel's pore as sensed by …
properties of the ion-conducting pore of the mechanoelectrical transducer channel of
sensory hair cells using permeant blockers. By combining results from experiments with
three classes of large cationic permeant blockers, the fluorescent dye FM1-43, the
aminoglycoside antibiotics, and the potassium-sparing diuretic amiloride, information has
been obtained on the free energy profile along the transducer channel's pore as sensed by …