[HTML][HTML] Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and …
JD Horton, I Shimomura, S Ikemoto… - Journal of Biological …, 2003 - ASBMB
Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound
transcription factors that regulate cholesterol and fatty acid homeostasis. In mammals, three
SREBP isoforms designated SREBP-1a, SREBP-1c, and SREBP-2 have been identified.
SREBP-1a and SREBP-1c are derived from the same gene by virtue of alternatively spliced
first exons. SREBP-1a has a longer transcriptional activation domain and is a more potent
transcriptional activator than SREBP-1c in cultured cells and liver. Here, we describe the …
transcription factors that regulate cholesterol and fatty acid homeostasis. In mammals, three
SREBP isoforms designated SREBP-1a, SREBP-1c, and SREBP-2 have been identified.
SREBP-1a and SREBP-1c are derived from the same gene by virtue of alternatively spliced
first exons. SREBP-1a has a longer transcriptional activation domain and is a more potent
transcriptional activator than SREBP-1c in cultured cells and liver. Here, we describe the …