Sterol regulatory element-binding protein (SREBP)-1c is now well established as a key
transcription factor for the regulation of lipogenic enzyme genes such as FAS in hepatocytes.
Meanwhile, the mechanisms of lipogenic gene regulation in adipocytes remain unclear.
Here, we demonstrate that those in adipocytes are independent of SREBP-1c. In adipocytes,
unlike in hepatocytes, the stimulation of SREBP-1c expression by liver X receptor agonist
does not accompany lipogenic gene upregulation, although nuclear SREBP-1c protein is …