Oxidative stress may be an important determinant of the severity of acute pancreatitis. One-
electron reduction of oxidants generates reactive oxygen species (ROS) via redox cycling,
whereas two-electron detoxification, eg by NAD (P) H: quinone oxidoreductase, does not.
The actions of menadione on ROS production and cell fate were compared with those of a
non-cycling analogue (2, 4-dimethoxy-2-methylnaphthalene (DMN)) using real-time
confocal microscopy of isolated perfused murine pancreatic acinar cells. Menadione …