Generation of plasmacytomas with the chromosomal translocation t (12; 15) in interleukin 6 transgenic mice.
S Suematsu, T Matsusaka, T Matsuda… - Proceedings of the …, 1992 - National Acad Sciences
S Suematsu, T Matsusaka, T Matsuda, S Ohno, J Miyazaki, K Yamamura, T Hirano…
Proceedings of the National Academy of Sciences, 1992•National Acad SciencesThe mechanisms through which pristane or mineral oil can induce plasmacytomas in
BALB/c or NZB mice are not fully understood, but involvement of interleukin 6 (IL-6), a
growth factor for plasmacytomas and myelomas, has been strongly suggested. To clarify the
role of IL-6 in plasmacytomagenesis, a human IL-6 cDNA was introduced into mouse germ
lines under the transcriptional control of the murine major histocompatibility complex class I
(H-2Ld) promoter. IL-6 transgenic mice of C57BL/6 origin developed a massive …
BALB/c or NZB mice are not fully understood, but involvement of interleukin 6 (IL-6), a
growth factor for plasmacytomas and myelomas, has been strongly suggested. To clarify the
role of IL-6 in plasmacytomagenesis, a human IL-6 cDNA was introduced into mouse germ
lines under the transcriptional control of the murine major histocompatibility complex class I
(H-2Ld) promoter. IL-6 transgenic mice of C57BL/6 origin developed a massive …
The mechanisms through which pristane or mineral oil can induce plasmacytomas in BALB/c or NZB mice are not fully understood, but involvement of interleukin 6 (IL-6), a growth factor for plasmacytomas and myelomas, has been strongly suggested. To clarify the role of IL-6 in plasmacytomagenesis, a human IL-6 cDNA was introduced into mouse germ lines under the transcriptional control of the murine major histocompatibility complex class I (H-2Ld) promoter. IL-6 transgenic mice of C57BL/6 origin developed a massive plasmacytosis but not plasmacytomas. However, introduction of BALB/c genetic background into IL-6 transgenic mice could generate monoclonal transplantable plasmacytomas with the chromosomal translocation t(12;15). These results provide firm evidence of the critical role of IL-6 in the plasmacytoma development.
National Acad Sciences