High-fat feeding protects mice from ventilator-induced lung injury, via neutrophil-independent mechanisms

MR Wilson, JE Petrie, MW Shaw, C Hu… - Critical Care …, 2017 - journals.lww.com
Objective: Obesity has a complex impact on acute respiratory distress syndrome patients,
being associated with increased likelihood of developing the syndrome but reduced
likelihood of dying. We propose that such observations are potentially explained by a model
in which obesity influences the iatrogenic injury that occurs subsequent to intensive care
admission. This study therefore investigated whether fat feeding protected mice from
ventilator-induced lung injury. Design: In vivo study. Setting: University research laboratory …