The impact of microsatellite stability status in colorectal cancer
Several forms of genomic instability are known to drive the development of colorectal cancer
(CRC). Chromosomal instability is the most common type found in 85% of the CRC, while
15% patients have microsatellite instability (MSI). MSI tumors are the subset of CRC that are
characterized by dysfunction of mismatch repair genes (MMR) causing failure to repair
errors in repetitive DNA sequences called microsatellites. Twelve percent of MSI tumors are
acquired, caused by methylation-associated silencing of a gene that encodes a DNA MMR …
(CRC). Chromosomal instability is the most common type found in 85% of the CRC, while
15% patients have microsatellite instability (MSI). MSI tumors are the subset of CRC that are
characterized by dysfunction of mismatch repair genes (MMR) causing failure to repair
errors in repetitive DNA sequences called microsatellites. Twelve percent of MSI tumors are
acquired, caused by methylation-associated silencing of a gene that encodes a DNA MMR …