[HTML][HTML] Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes
HV Lin, D Accili - Journal of biological chemistry, 2011 - ASBMB
Type 2 diabetes results from an impairment of insulin action. The first demonstrable
abnormality of insulin signaling is a decrease of insulin-dependent glucose disposal
followed by an increase in hepatic glucose production. In an attempt to dissect the relative
importance of these two changes in disease progression, we have employed genetic knock-
outs/knock-ins of the insulin receptor. Previously, we demonstrated that insulin receptor
knock-out mice (Insr−/−) could be rescued from diabetes by reconstitution of insulin …
abnormality of insulin signaling is a decrease of insulin-dependent glucose disposal
followed by an increase in hepatic glucose production. In an attempt to dissect the relative
importance of these two changes in disease progression, we have employed genetic knock-
outs/knock-ins of the insulin receptor. Previously, we demonstrated that insulin receptor
knock-out mice (Insr−/−) could be rescued from diabetes by reconstitution of insulin …