Functional variants of the HMGA1 gene and type 2 diabetes mellitus
E Chiefari, S Tanyolaš, F Paonessa, CR Pullinger… - Jama, 2011 - jamanetwork.com
Context High-mobility group A1 (HMGA1) protein is a key regulator of insulin receptor
(INSR) gene expression. We previously identified a functional HMGA1 gene variant in 2
insulin-resistant patients with decreased INSR expression and type 2 diabetes mellitus
(DM). Objective To examine the association of HMGA1 gene variants with type 2 DM.
Design, Settings, and Participants Case-control study that analyzed the HMGA1 gene in
patients with type 2 DM and controls from 3 populations of white European ancestry. Italian …
(INSR) gene expression. We previously identified a functional HMGA1 gene variant in 2
insulin-resistant patients with decreased INSR expression and type 2 diabetes mellitus
(DM). Objective To examine the association of HMGA1 gene variants with type 2 DM.
Design, Settings, and Participants Case-control study that analyzed the HMGA1 gene in
patients with type 2 DM and controls from 3 populations of white European ancestry. Italian …