[HTML][HTML] Mutual dependence of Foxo3a and PGC-1α in the induction of oxidative stress genes

Y Olmos, I Valle, S Borniquel, A Tierrez, E Soria… - Journal of Biological …, 2009 - ASBMB
Oxidative stress is a hallmark of metabolism-related diseases and a risk factor for
atherosclerosis. FoxO factors have been shown to play a key role in vascular endothelial
development and homeostasis. Foxo3a can protect quiescent cells from oxidative stress
through the regulation of detoxification genes such as sod2 and catalase. Here we show that
Foxo3a is a direct transcriptional regulator of a group of oxidative stress protection genes in
vascular endothelial cells. Importantly, Foxo3a activity requires the transcriptional co …